Major Depressive Disorder

Middle-aged men with prediabetes are more likely than healthy peers to suffer from depressive symptoms and signs of andropausal syndrome.

Study results suggest that more than 80% of patients with depression in the general population appear to not be eligible for clinical trials of antidepressant medications.

An article in Schizophrenia Bulletin makes a strong case for a scaling up of schizophrenia care that could yield breakthroughs in treatment for the condition and, ultimately, many other mental health disorders. Such a scaling up would involve breaking down significant barriers but could yield significant breakthroughs in treatment.

A study in Translational Psychiatry has identified three potential genes that could prove to be responsible for disturbances in mitochondrial function and DNA repair mechanisms in bipolar disorder. The genes in question – POLG, OGG1, and NDUFV2 – may open new targets for examination. The study authors themselves consider the results to be "somewhat promising."

Children with systemic lupus erythematosus (SLE)/mixed connective tissue disease (MCTD) often suffer from significant bouts of depression and potentially suicide ideation, a study in the Journal of Pediatrics determined.

Two comprehensive reviews in the Indian Journal of Psychiatry looked at the use of pharmacologic therapy for psychiatric conditions during pregnancy and lactation. One review looked at mood stabilizers and the other focused on antidepressants, anxiolytics, and hypnotics.

Researchers seek to determine whether depression subtype is an useful predictor of which medication regimen might be most effective in treating patients with those subtypes.

Not only have researchers from Mount Sinai Hospital discovered that common antidepressants can help treat neuropathy, but they also identified the gene associated with pain and depression.

Children with multiple sclerosis (MS) with higher levels of physical activity have lower relapse rates, are less depressed, and suffer less fatigue, according to a study published on August 12, 2015 in Neurology.

Low vitamin D levels in otherwise healthy young women may increase their risk for depression, according to findings published in Psychiatry Research.

A systematic review of alopecia areata (AA) in Clinical, Cosmetic & Investigational Dermatology highlighted the unpredictability and lack of treatment options for the condition. But it also pointed to a larger problem: more than half of patients with AA experience poor health-related quality of life (QOL). Patients with AA are at risk for depression and anxiety, atopy, vitiligo, thyroid disease, and other autoimmune conditions.

Investigators have shown that changes in toll-like receptor 4 (TLR4) mRNA expression level are significantly associated with major depressive disorder (MDD). The study, which appeared in Neuropsychiatric Disease and Treatment, is a follow-up to an earlier study by the same researchers that first established the connection between TLR4 and MDD.

Regarding pulmonary and mental health, an emerging study has reported teen marijuana use is not associated to the development of several conditions including depression, psychosis, allergies, headaches, or high blood pressure.

Cardiovascular disease is the most common comorbidity in patients with rheumatoid arthritis (RA) and the reason behind it may have finally been identified.

Australian research indicates that ultra-brief pulse stimulation is nearly as effective as standard electroconvulsive therapy (ECT) for the treatment of severe depression, but with substantially fewer cognitive side effects.

Self-management for chronic or long-term conditions such as pain, diabetes, asthma, or arthritis is now a common part of long-term care. The same is not true for depression. At least, not yet. As clinicians learn more about depression, it has ceased to be viewed alongside other acute conditions and is now often thought of as chronic or long-term. Research shows that more than half of all people will have at least one further depressive episode after their first.

Although a seemingly invisible condition, fibromyalgia (FM) may have an important connection with mental health symptoms.

Studies have shown that major depressive disorder (MDD) has a strong link to genetic factors, and many clinicians and researchers believe the same to be true for obesity.

Study results show that mood, whether positive or negative, may impact the discomfort associated with rheumatoid arthritis.

A clinical trial is evaluating the use of the Kokoro app to deliver a smartphone-based CBT program to patients being treated for depression.

A study evaluating glycemic response following insulin initiation for type 2 diabetes mellitus found that patients with higher depression parameters or distress at baseline had significantly higher rates of microvascular complications at baseline and higher HbA1c levels.

The US Food and Drug Administration (FDA) announced the approval of Rexulti (brexpiprazole) as a treatment option for adults with schizophrenia or major depressive disorder (MDD).

Often, pain associated with rheumatoid arthritis (RA) can impact every aspect of a person's life, leading to isolation, depression, anxiety, lack of physical activity, and a host of other ills. Most experts agree that self-support tools-along with emotional support from loved ones, fellow RA patients, health care providers, and friends-is a key component of managing RA.

Opioid analgesics are often prescribed to patients who suffer from chronic lower back pain; however, a new report suggests that these medications are less effective in a subset of these patients.

Study results indicate that low-field magnetic stimulation synchronized to an individual's alpha frequency-dubbed "synchronized transcranial magnetic stimulation"-appears to be safe, effective, and well tolerated for treating major depressive disorder when properly administered.

Study results suggest that brain inflammation resulting from chronic nerve pain appears to alter activity in brain regions that regulate mood and motivation. The findings indicate, for the first time, a direct biophysical relationship between long-term pain and the co-morbid anxiety, depression, and substance abuse observed in more than 50% of patients with chronic nerve pain.

While cognitive behavioral therapy has been used to treat patients with insomnia, evidence backing the treatment for those who also have other psychiatric and medical conditions has not been available until now.

Bereavement and depression may have similar symptoms, but should remain clinically differentiated, according to researchers from KU Leuven in Belgium.

While treating our patients' depression is a crucial aspect of sound pain management practice in primary care, the analgesic effects of certain antidepressants, particularly for select types of chronic pain, should also not be underestimated.

A large percentage of acute lung injury survivors in the ICU may have clinically significant general anxiety, depression, or post-traumatic stress disorder symptoms that tend to co-occur across domains.