Type 2 Diabetes

The Paradox: SGLT2 inhibitors should cause 100% inhibition of SGLT2 in humans. They only inhibit by 30%-50%. Why?

All 3 once-weekly GLP-1 RAs effectively reduce A1c and promote weight loss. Similarities and important differences are parsed in these slides.

This novel study examines the effect of adding another oral agent, rather than insulin, to patients with type 2 diabetes not controlled on metformin plus exenatide.

It's easy to burn out and much harder to slow down in day-to-day medical practice. I found a simple process that might help fan the flame when it sputters.

Another investigational diabetes drug appears to have promise for patients with nonalcoholic steatohepatitis, researchers reported at the International Liver Congress in Vienna, Austria.

An estimated 11,000 attendees from 105 countries are converging in Vienna, Austria for the 50th International Liver Congress, hosted by the European Association for the Study of the Liver (ILC/EASL). Some 200 journalists -- including a team from MD Magazine--are on hand to report the news. Eagerly awaited trials include those of two drugs that show promise for treating a common liver disease associated with obesity, known medically as non-alcoholic steatohepatitis (NASH) and its precursor non-alcoholic fatty liver disease (NAFLD).

The Choosing Wisely project offers specific, evidence-based recommendations providers and patients should discuss to make determine each individual patient's most appropriate care.

Patients with diabetes may need prompting and encouragement to meet recommended levels of eye care. Having health insurance coverage doesn't seem to increase adherence to this recommendation.

The American Diabetes Association recommends eating fewer calories of better quality to prevent diabetes. Researchers looked at the available evidence from studies that examined a variety of diets and found that any healthy diet reduces the risk of diabetes by about 20%.

With more than 40 million Americans either diagnosed or at high risk for osteoporosis as they age, researchers are scrambling to find ideal preventive and curative agents. One target that strengthens bones is excessive osteoclast activity. A team of researchers recently found that one biologic that targets excessive osteoclast activity may positively influence another problem of later life: insulin sensitivity.

“Doctor” comes from the Latin docēre, “to teach.”

A common concern of expectant parents is what can increase the likelihood of their children being diagnosed with autism. A recent study found a link between exposure to gestational diabetes and autism risk.

The size of the incretin effect among healthy subjects may vary up to 2-fold, suggesting differences in ß-cell sensitivity to GLP-1. Does BMI play a role in this variability?

Try your hand at this first in a series of questions on combination drug therapy to optimize treatment of T2DM.

This extension trial is the longest to track efficacy/tolerability of a novel vs more traditional agent as add-on therapy for uncontrolled type 2 diabetes.

Albumin -- the most abundant protein in the human body -- has many roles. It transports hormones, fatty acids, and other compounds. It buffers serum pH, and maintains osmotic pressure. Now, it appears that albumin may be a tool that could be used in diabetes management.

Gabapentin is used to treat neuropathic pain from several causes, including diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain. In a study presented at the American Society of Interventional Pain Physicians in Orlando, FL, April 11, Tobore Onojighofia, MD, MPH and colleagues found genetics plays a role in which patients do well on the drug.

An advisory panel for the US Food and Drug Administration (FDA) held a hearing yesterday focusing on safety issues associated with two diabetes medications. Although the panel's recommendation did not include specific treatment changes, its decision highlighted the fact that more research is needed on cardiovascular risk associated with this class of diabetes medications.

Adherent patients were more likely to achieve at least a 1.0% drop in A1c; half achieved the ADA-prescribed goal of <7%. Higher cost was not a surprise.

Lack of sleep and chronic kidney disease (CKD) independently lead to hypertension, diabetes mellitus, lower quality of life, and shorter life expectancy. Severity of CKD and sleep disturbances may also worsen diabetes and hypertension synergistically.

RM is an active 78-year-old woman with no complaints about her health or her medications. Then she tells you about her home blood glucose readings.

While TORe has been a significant development in the treatment of overweight and obese patients who have undergone gastric bypass surgery there are more procedures on the horizon that could provide even greater benefits in the future.

Even more so than gastric bypass surgery, the work of the patient determines how effective TORe can be in helping them keep from re-gaining excess weight. With diet, exercise, and working with their healthcare professionals the results can be positive for everyone involved.

While gastric bypass has provided benefits for millions of patients it has not been without its share of complications and difficulties after the procedure. Over the past few years work has been done to find ways to help patients after undergoing the original operation.

Across the country millions of people have undergone gastric bypass surgery in an effort to lose weight and improve their overall health. For those patients who have seen their results diminish a relatively new procedure could get them back on the road to a healthy lifestyle.

Authors of a new study note that an observed link between antibiotics and diabetes risk may be yet another result of changing levels and diversity of gut bacteria.

In states that expanded the number of low-income people eligible for Medicaid under the Affordable Care Act, the number of people with newly diagnosed type 2 diabetes increased by 23 percent.

Monitoring blood glucose levels can be an important part of daily treatment for diabetes patients, but a recent look at one particular population considered whether some could be overly using their monitoring equipment.