Type 2 Diabetes

Study results presented at ADA 2014 show combination treatment with metformin plus linagliptin delivered consistent HbA1c reductions across different subgroups of patients newly diagnosed with type 2 diabetes, with decreased risk of hypoglycemia.

In response to the growing prevalence of gestational diabetes mellitus and its associated morbidities, much attention has been paid to the use of appropriate screening methodologies for the metabolic disorder.

Study results show that an alternative to currently-marketed injectable agents retains the efficacy of GLP-1 mimetics, while reducing gastrointestinal adverse events and providing the convenience of oral dosing.

Results from the largest population-based, case-control study on the link between incretin therapy and pancreatitis conducted to date indicate that treatment with this class of medications does not confer increased risk of developing pancreatitis.

Combination treatment with insulin degludec and liraglutide was associated with long-term reductions in HbA1c, reduced hypoglycemia risk, and fewer gastrointestinal side effects compared to treatment with the individual medications alone in patients with diabetes.

Patients treated with a new, more concentrated insulin glargine formulation experienced similar glycemic control with fewer nocturnal and daytime hypoglycemic events compared with patients treated with the current formulation of the product.

Study results presented at ADA 2014 show Eli Lilly's investigational long-acting basal insulin analog to have similar clinical efficacy in reducing HbA1c levels as a currently approved injectable insulin glargine product, with a comparable side effect profile.

An A1C goal less stringent than 7% may be appropriate for some patients. In what patients might you make the goal 8%?

For which patients might a less stringent A1C goal -- of 8% -- be appropriate? A quiz, and the answer here.

Just weeks after Australian researchers published data suggesting that testosterone replacement therapy does not ameliorate type 2 diabetes among hypogonadal men, a team of American researchers has unveiled a second study that suggests just the opposite.

The rate of all-cause death was higher in patients who received insulin. Heart attack and stroke rates were statistically similar.

Current ADA diagnostic criteria are summarized here.

Women receive less aggressive screening for and care of cardiovascular risk factors than men. The sex disparity places women with diabetes at particular risk for CVD morbidity.

Women tend to be diagnosed with cardiovascular disease later in life than men. But a diagnosis of type 2 diabetes in a woman appears to nullify a gender-protective effect.

Findings from a pair of ongoing studies into the effects of testosterone replacement therapy indicate unexpected significant improvements for obese patients.

What's the connection between type 2 diabetes and rhinocerebral mucormycosis? Here's a case in point.

After studying an Amish population, researchers at the University of Maryland Medical Center have discovered a mutation in a fat-storage gene that increases a patient's risk for type 2 diabetes.

Diagnoses of type 2 diabetes among US youth increased three-fold between 2001 and 2009. These children will enter their 20s with adult complications. Here, how to help stem the tide.

It is primarily the responsibility of parents, teachers, and health care professionals to be role models for the younger generation with respect to healthy eating and physical activity.

Significant advances have resulted in nearly equal 5-year survival rates for patients with and without diabetes.

Increases were significant in both type 1 and type 2 diabetes, according to a new study, possibly leading to further increases in the next generation.

Total number of hospitalizations increased by more than 23%, while associated treatment costs rose but mortality declined.

A 36-year-old pregnant woman at 27 weeks gestation presented to the obstetrical triage for evaluation of possible abscess due to a lesion on her buttock that first appeared 1 week ago. Since that time, it has become increasingly painful and itchy. Although she denies any systemic symptoms, her pregnancy is complicated by gestational diabetes and obesity. However, she is HIV negative and her other prenatal labs were unremarkable.

Study of obese men with low testosterone and type 2 diabetes showed no benefits from treatment with intramuscular testosterone undecanote in glucose metabolism or visceral adiposity.

Bariatric surgery represents a potentially useful intervention for managing obese type 2 diabetics who would fail to reach treatment goals with intensive medical therapy alone.

Since inactivity accounts for 10-16% of breast cancers, colon cancers, and diabetes cases, as well as 22% of heart disease, some researchers believe too much sitting can cause just as much harm as smoking.

Despite intensive subcutaneous insulin therapy, a relatively small group of type 1 diabetics fails to reach adequate glycemic control, has frequent hypoglycemic episodes, or develops insulin resistance.

Do you recognize these symptomatic red patches and plaques? What underlying disorder does the condition imply?

Since nearly half of all Staphylococcus aureus infections harbor difficult-to-cure methicillin-resistant (MRSA) isolates, identifying MRSA risk factors could improve infection prevention and treatment, as well as reduce resistance patterns.

The observed insulin responses to sustained hypoxia at high altitudes has prompted deeper inquiry into the role of oxidative stress in the pathophysiology of type 2 diabetes.