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Adult male hypogonadism (HG) is the most common form of diminished gonadal activity in men. Most clinicians prescribe testosterone replacement therapy to treat primary HG, but other therapeutic options are available.

Renal clearance can be significantly elevated in the critically ill. Treating these patients with renally cleared drugs can present a problem. Drugs-whisked through the body with greater than expected efficiency, a process called augmented renal clearance (ARC)-reach only suboptimal levels and, consequently, patients experience no improvement or actual clinical decline. ARC is often associated with elevated urinary creatinine clearance.

In March 2014, the Society of Surgical Oncology Susan G. Komen for the Cure Symposium focused on the literature on the epidemiology, molecular pathology, and therapy considerations of triple-negative breast cancer. The Annals of Surgical Oncology has published a summary of this work ahead of print.

Since children diagnosed with autism spectrum disorders (ASD) may also have epileptic disorders, physicians usually want electroencephalograms (EEGs) of their brains.One sign of autism is staring spells. That can also be a form of epilepsy, an absence seizure.But an Australian study of children referred for these episodes showed EEGs offer little diagnostic benefit.

The US Food and Drug Administration approved the first generic version of AstraZeneca's heartburn blockbuster, Nexium.

Abandonment alters children's brain tissue.Children who experienced extreme neglect showed physical changes in the white matter of their brains, a Boston team found.Writing in JAMA Pediatrics Johanna Bick PhD and colleagues at Boston Children's Hospital reported on the Bucharest Early Intervention Project.

Finding brain beta amyloid is usefull in assessing Alzheimer's Disease. In a report in JAMA Neurology, Craig Curtis, MD, and colleagues report on a multicenter PET imaging study on terminally ill dementia patients using flutemetamol injections tagged with radioactive fluorine 18. In cases where autopsy was later possible, the team assessed how accurate the tests had been in diagnosing Alzheimer's.

Isolated systolic hypertension (ISH) in young and middle-aged adults is on the rise. A study in the Journal of the American College of Cardiology found that ISH puts these patients at higher relative risk for heart disease and mortality than their peers with normal blood pressure. That raises the question of whether these younger ISH patients should be getting drug therapy.

As a blizzard predicted to break snowfall records bears down upon the Northeast, hospitals and physicians are shifting into disaster-planning mode. With the worst of the blizzard expected to hit coastal New England, Mass. Gov. Charlie Baker has declared a state of emergency and instituted a travel ban that will take effect at midnight. , per Boston.com. Shriner's Hospital in Boston canceled elective procedures and clinic visits. New Jersey Gov. Chris Christie declared a state of emergency at noon Monday, closing state offices and urging motorists to stay off the roads. In a news conference this afternoon, he said the state's emergency workers and transportation department can handle the storm.

Researchers have developed a safer method for testing d-dimer values in patients over the age of 50 years, according to research published in the journal CHEST.

Researchers from the University of Massachusetts Amherst will investigate if a blood test can predict breast cancer.

The US Food and Drug Administration (FDA) has approved a polypill for hypertension, a combination of perindopril arginine and amlodipine (Prestalia/ Symplmed Pharma-Servier).

Researchers at the Washington University School of Medicine, St. Louis, WA, had recently discovered the correlation between inflammatory bowel disease (IBD) and the steady increase in the diversity of viruses.

The optimal treatment time for slowing the progression of rheumatoid arthritis is earlier in the course of disease, researchers said in the Annals of Rheumatic Diseases.

The progression of aging can be tracked – and even slowed – by a blood test that can also possibly detect early warning signs of more serious illnesses.

The US Food and Drug Administration approved ferric pyrophosphate citrate (Triferic/Rockwell) for use as an iron replacement therapy in patients with end-stage renal disease, the company announced. It is also indicated for chronic kidney disease. The drug is for adults.

A new test will aim to determine if vibrating soles can prevent falls in patients with multiple sclerosis, by training them to strengthen muscles and balance.

Facial fractures are a frequent cause for emergency department (ED) visits, costing the US economy about $1 billion every year. These fractures can occur due to a variety of traumas, including motor vehicle accidents, sports injuries, person-to-person violence, and falls. Identifying trends could help ED personnel and surgeons anticipate common problems.

The US Food and Drug Administration (FDA) approved Bexsero, a Novartis vaccine to prevent meningococcal disease caused by Neisseria meningitides serogroup B. It is meant for children age 10 and up and young adults through age 25.

Researchers recently used a 3-D printer to create case-specific models that can aid in accurate, extensive preoperative planning.

Handwritten prescriptions will soon be illegal in New York. The Medical Society of the State of New York (MSSNY) and 18 national and NY State medical organizations are trying to delay for a year the onset of a law that would require electonic prescriptions, ban prescription pads, and drastically restrict phoned-in prescriptions. The measure, due to take effect March 27, would require electronic prescriptions for all medications-not just for controlled substances but antibiotics, allergy medications or anything else that requires a prescription.

Patients can develop symptoms of both COPD and asthma, and the percentage increases as patients age.

Breast cancer patients who believed acupuncture would reduce their joint pain demonstrated significant pain reduction, no matter if they received real or placebo acupuncture.

Rheumatoid arthritis patients may get relief from a selective cannabinoid receptor agonist, according to findings published in BMC Musculoskeletal Disorders.

Study shows that regular acetaminophen use may be associated with an increased risk of psoriasis and psoriatic arthritis (PsA), and that long-term NSAID use may be associated with an increased risk of PsA.

A commonly used sensitive Troponin detection test to confirm heart attacks is often not being used in a way that will consistently detect these events, a UK research team has found. Writing in the British Medical Journal, Zhivko Zhelev PhD, a diagnostics research fellow at the University of Exeter and colleagues reported on their meta-analysis of studies that assessed the accuracy of a widely used diagnostic test, the Elecsys Troponin T high-sensitivity assay.

Study results show patients with psoriatic arthritis, rheumatoid arthritis, and psoriasis are at higher risk for myocardial infarction, stroke, and other adverse cardiovascular events.

The hospital shooting death of Boston cardiac surgeon Michael Davidson, MD, 44, has shocked the cardiology world-far beyond his colleagues at Brigham and Women's Hospital where he was director of endovascular cardiac surgery. On a remembrance page and in formal statements, tributes are pouring in. Davidson, a respected innovator in heart valve replacement, died late Jan. 20, hours after he was shot by the son of a former patient who then turned his gun on himself.He leaves his wife Teri Davidson, who is 7 months pregnant, and 3 children ages 2 to 9.

The US Food and Drug Administration (FDA) approved secukinumab (Cosentyx/Novartis) for adults with moderate to severe plaque psoriasis. The European Commission approved the same drug on Jan. 19. Its active ingredient is an antibody that binds to interleukin-17A and interferes with inflammation. The binding prevents that protein from triggering the inflammatory response that results in psoriasis patches.