Rapid Treatment Crucial in Herpes Encephalitis
September 4th 2015The largest case series to date of outcomes in patients with herpetic meningoencephalits (HME) shows early diagnosis and treatment is critical if the damage is to be held in check. Rapid treatment is common in the US, but globally, a Turkish researcher found, delays of days or even a week are not uncommon.
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Study: No HIV in Hundreds of Gay Men Taking Preventive Drug
September 3rd 2015An observational study of 657 people at high risk of getting HIV infections found that Gilead's Truvada taken daily has prevented them from getting the virus. The CDC is promoting the drug regimen in a campaign called PrEP, for pre-exposure prophylaxis.
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Wire-Free Pacemaker Shows Promise
September 1st 2015New York City-based researchers reported that a leadless cardiac pacemaker (Nanostim/St. Jude Medical) implanted non-surgically via a catheter through the femoral vein had a better safety record than conventional devices. But it has other limitations.
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PCSK9 Inhibitor Dramatically Reduces Cholesterol in Patients with Familial Hypercholesterolemia
September 1st 2015The Sanofi/Regeneron PCSK9 inhibitor alirocumab (Praluent)- approved in July in the US - lowered cholesterol in patients with familial hypercholesterolemia to levels "unreachable with statins" researchers said at the European Society of Cardiology meeting in London, UK.
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Does Religion Belong in the ICU?
August 31st 2015Close relatives or friends often serve as surrogate decision-makers for patients in intensive care units. Physicians are usually comfortable answering their medical questions. But what happens when spiritual or religious issues arise in the context of end-of-life decisions?
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Finerenone vs. Eplerenone: Trial Shows Mixed Results
August 31st 2015In heart failure patients with diabetes and/or chronic kidney disease, a new, non-steroidal mineralocorticoid receptor antagonist called finerenone was no more effective than the currently approved MRA eplerenone in reducing the heart failure biomarker N-terminal pro-B-type natriuretic peptide. But it had other benefits.
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Study: NSAIDs, COX-2 inhibitors Have Equivalent Side Effects
August 31st 2015Researchers in Scotland found that in a trial involving more tha n 7,000 patients, the rates of adverse cardiac and other negative outcomes were about the same whether these patients took NSAIDs or COX-2 inhibitors.
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FDA Warning: Disabling Joint Pain Seen in Diabetes Drugs
August 28th 2015The US Food and Drug administration today issued a warning that the type 2 diabetes medicines sitagliptin (Januvia/Merck) linagliptin (Tradjenta/BI), and alogliptin (Nesina/Takeda) "may cause joint pain that can be severe and disabling."
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FDA Approves Another PCSK9 Inhibitor
August 28th 2015The US Food and Drug Administration last night announced it has approved evolocumab (Repatha/Amgen), an injectable drug for some patients who are unable to get their LDL cholesterol under control. Statins are a cheaper and generally effective treatment, but the new class of drugs is expected to help people who cannot tolerate them, for whom they do not work, and for people with heterozygous familial hypercholesterolemia.
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New Glycemic Control Combo Approved for Type 2 Diabetes
August 27th 2015The US Food and Drug Administration approved a new glycemic control treatment for type 2 diabetes for adults, a combination product made of empagliflozin (Jardiance/ Boehringer Ingelheim) and metformin hydrochloride. It will be marketed as Synjardy in a joint venture with Eli Lilly.
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Study: Exercise, Vitamins Failed to Prevent Cognitive Decline in Older People
August 25th 2015To keep their minds sharp, older people are often advised to take vitamins or other dietary supplements and to engage in regular exercise. Two studies in JAMA show those practices had no effect on cognitive function.
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Brain Tumors: Girls Survive Longer
August 18th 2015Weill-Cornell researchers looking into genetic differences in high-grade gliomas made an unexpected finding: while both boys and girls live longer when their visible tumors are completely removed, the girls lived almost six years longer post-surgery.
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Q&A With Samir Kapadia From Cleveland Clinic: TAVR Gives Patients New Chance at Life in Later Years
August 17th 2015A whole new segment of the population, particularly elderly patients are now eligible for a lifesaving cardiac procedure with the development of Transcatheter Aortic Valve Replacement or TAVR.
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Study: Hi-Dose Vitamin D Shows No Benefit for Postmenopausal Women
August 3rd 2015Postmenopausal women who took high doses of Vitamin D showed no improvement in bone mineral density, muscle function, muscle mass or frequency of falls, Wisconsin researchers found. In a study reported in JAMA Internal Medicine high-dose cholecalciferol therapy increased calcium absorption "but the effect was small and did not translate into beneficial effects," Karen Hansen, MD and colleagues wrote.
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