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Tuberculin Skin Testing: Methods and IndicationsThe tuberculin skin test is the most frequently used method for detecting asymptomatic latent tuberculosis infection. There is growing interest in other diagnostic tests for latent infection that might be simpler to administer, but the tuberculin skin test remains the preferred modality because of its ease of use and low cost. The decision to perform an annual test or a single test depends on the population each specific patient represents. Interpretation of the reaction to the test should be done by trained health care professionals, keeping in mind that factors such as immunization can cause false-negative or false-positive results.
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Drug Diversion and Abuse: Operation Medicine CabinetA recent safe disposal prescription initiative in Florida should serve as a guide for other counties throughout the country to help curb prescription drug diversion.
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Free Zinc Regulation Could Be Key to Stopping AMD Development and ProgressionZinc is the second most abundant trace element in the human body after iron, and is present in high concentration in the human eye.
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Diabetic cardiomyopathyDiabetic cardiomyopathy is a clinical condition characterized by altered myocardial function in the absence of coronary artery disease, hypertension, and valvular or congenital heart disease. Patients with this condition exhibit changes in cardiac structure that may be attributed to the direct effect of diabetes mellitus. The author discusses the mechanisms, risk factors, screening, diagnosis, prevention, and treatment of cardiomyopathy in patients with diabetes.
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Post-marketing Vaccine Safety SurveillanceSafety and adverse event monitoring don't stop when a vaccine is approved.
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Human Trials Could Begin for Macular Degeneration Stem Cell TherapyFDA trial approval would make this trial the first ever to test a stem cell-based therapy derived from induced pluripotent stem cells for treating any disease.
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Making Healthy Choices for LifeThe advances in cancer therapies and the growing number of people who get screened regularly for various cancers has led to better rates of overall survival in many solid tumors and hematological malignancies.
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Cardiac catheterization in higher-risk NSTE-ACS patients: Why is it being underutilized by physicians?We compared the rates of cardiac catheterization in 2136 non–ST-segment elevation acute coronary syndrome patients who were stratified according to their baseline thrombolysis in myocardial infarction (TIMI) risk score. Higher-risk patients were referred for catheterization at a similar rate as low-risk patients. The main reasons why physicians did not make referrals included (1) clinical trial evidence did not support an early invasive approach and (2) 68% of patients were thought not to be at high enough risk; however, 59% of these patients were found to be higher risk when their baseline TIMI risk scores were recalculated. Patients who were referred for catheterization had better in-hospital and 1-year outcomes. Our findings indicate that a significant opportunity remains to improve upon accurate risk stratification and adherence to an early invasive strategy for higher-risk patients.
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Asthma Patients Require Increased Detection of Dysfunctional BreathingDysfunctional breathing is a common comorbidity in patients with severe asthma, and is associated with increased patient anxiety and depression.
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Procainamide-induced Pleural and Pericardial EffusionsDrug-induced diseases and serious adverse drug effects can alter therapeutic plans and greatly affect patient outcomes. Many medications are known to have a narrow therapeutic index and to require close patient monitoring.
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Extreme lipoprotein(a) levels and myocardial infarctionWe conducted a study to determine whether high lipoprotein(a) levels predicted the risk of myocardial infarction (MI) and ischemic heart disease. Unlike other studies, we measured lipoprotein(a) levels shortly after sampling and corrected for regression dilution bias.
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Advice for Physicians to Manage C. Difficile Infection (CDI)Experts share advice for physicians taking care of patients with C. difficile infection (CDI).
