Hepatitis C

Some traditional sarcopenia assessment techniques included direct measurements on cross sectional imaging, but cross sectional imaging also comes with increased time, cost, and radiation exposure.

Using the bidirectional Montreal classification system, which accounts for disease regression, showed that 90% of patients exhibited inflammatory disease behavior at 5 years, compared to 58% if the hierarchical, unidirectional Montreal classification system was implemented.

April is Donate Life Month, where many advocate for more living organ donors.

Of the patients in the first cohort, 0.7% had HBV, all of which had a history of drug use. In addition, 3% were anti-HCV positive, 8 of which had a history of drug.

Metabolic dysfunction was associated with increased risk of HCC, while patients with only metabolic dysfunction had the highest risk because the sustained virological response achievement.

The cumulative probabilities of treatment initiation after meeting the criteria was not significantly different between the different racial groups and the incidence of major adverse liver outcomes was 0.1 per 100 person-years and did not differ by race.

The investigators found having at least 1 risk factor increased the odds of having an HCV-positive result by 20% compared to the population without risk factors.

The proportion of AUD treatment engagement did not differ between the 2 time periods, but intervention increased intermediate outcomes, including screening, new AUD diagnosis, and treatment initiation.

A nearly two-fold increase or decrease in liver stiffness would be required to confidently represent a change in the underlying fibrosis.

There was an 88.12% cure rate in the intention-to-treat analysis.

There is a June 22 PDUFA date for obeticholic acid, which if approved would become the first FDA-approved treatment for NASH.

No single biomarker or multimarker score significantly reached the predefined acceptability thresholds for patients with NASH and clinically significant fibrosis.

Liver stiffness, body weight, and metabolic risk factors were significantly and comparably reduced in both groups.

The new guidance is the first update since 2008, replacing the previous risk-based recommendations.

There were increases in fibrosis stage for 24% of patients in the rifaximin-α group, compared to 43% of the placebo group.

The odds of hospitalizations with acetaminophen and opioid toxicity increased by 11% per year prior to the mandate and decreased by 11% per year after the announcement.

The gene expression analysis of the liver showed mRNA levels of BCAT1, BCAT2, and BCKDA were upregulated in patients with NAFLD.

Individuals that did not respond had a lower percentage of naïve T cells compared to responders, while responders had a lower percentage of Th2 and CD4 central memory subsets before vaccination.

HCV RNA positivity was significantly more prevalent in the male patient than it was for females in both adults and the general population after excluding high-risk groups.

Acceptability of the vaccine was high among the completers and some non-completers that felt it was safe and offered them protection.

Sofosbuvir-based regimens were the most commonly prescribed therapies to treat hepatitis C virus in Asia, Africa, and the Commonwealth of Independent States.

Kim Zuber, PA-C, and Jane Davis, DNP, provide perspective on guideline recommendations for the management of hepatitis C in people with chronic kidney disease from the Kidney Disease Improving Global Outcomes.

Latino-English preferred patients had an overall lower rate of screening compared to both non-Hispanic whites and Latino-Spanish preferred patients.

Amid a blood shortage and continued stigmatization of HIV risk, it's hard to feel good about the FDA's delayed decision—though good may still come of it.

While 20% of the patient population had a Fib-4 index greater than 1.3, including 1 case of a Fib-4 index greater than 2.67, the investigators did not identify a significant increase in Fib-4 index in patients with fatty liver compared to those who did not develop fatty liver.

The majority of healthcare workers included in the study were immune to both measles and rubella.

Patients with HCC were more likely to be older, male, Asian, and have a history of hepatitis B virus.

There have been more than 12,900 studies on the involvement of dysbiosis in the gensisinfectious diseases in the last 15 years.

The number needed to screen to detect unknown anti-HCV positive individual was 262 for those unaware of their infections.

More patients are presenting with later stage liver cancer due to missed screenings during the COVID-19 pandemic.