The HCPLive conference coverage page features articles, videos, and expert-led live coverage from major medical meetings throughout the year.
Brigit Vogel, MD: Exploring Geographical Disparities in PAD Care Across US
Birgit Vogel, MD discusses racial inequities and geographic variations in peripheral artery disease care in the United States.
Eric Lawitz, MD: FXR Agonists for MASH, What FXR314 May Offer for Safety, Efficacy
Lawitz explains issues with traditional FXR agonists for MASH treatment and how FXR314 differs, potentially offering a more safe and efficacious option.
Megan Clowse, MD, MPH: Improving Disease and Reducing Corticosteroids in SLE With DZP
Clowse discussed findings from the phase 3 PHOENYCS GO trial presented at the 2024 ACR Convergence.
Milind Desai, MD: Real-World Safety Data Supports Mavacamten for oHCM
Milind Desai, MD describes favorable real-world safety outcomes from mavacamten use over 22 months of the Risk Evaluation and Mitigation Strategy (REMS) program.
Children with IBD Respond Well to the Pfizer COVID-19 Vaccination, with Arthur Kastl, MD
HCPLive spoke with Kastl at NASPGHAN about the team’s study on the immune response to the COVID-19 vaccination among children with IBD.
Rohit Loomba, MD: Promising Phase 2a HERALD Data for ALG-055009 in MASH
Loomba reviews safety and efficacy data for the thyroid hormone receptor beta agonist from a phase 2a trial presented at AASLD The Liver Meeting 2024.
Open-Label Study Finds Aficamten Could Help Most oHCM Patients Avoid Surgery
Ahmad Masri, MD, MS, discusses data from the FOREST-HCM trial examining effects of aficamten in patients with oHCM eligible for septal reduction therapy at baseline.
Recent Advances Have Improved Prognosis in ATTR-CM Patients, with Ahmad Masri, MD, MS
Ahmad Masri, MD, MS, discusses a study from AHA 2024 detailing changing risk profiles and outcomes in trials among patients with ATTR-CM.
AI Assessments, Robotics Perform to Rheumatologist Levels in Joint Assessment
Data from 2 studies presented at ACR 2024 demonstrate the potential of AI to improve access to quality rheumatological assessments.
Phase 2 Data Support Muvalaplin for Lowering Lp(a), with Stephen Nicholls, MBBS, PhD
Stephen Nicholls, MBBS, PhD, provides additional insight into KRAKEN trial data and the potential of muvalaplin.
Marianna Fontana, MD, PhD: Nex-Z Shows Promise in ATTR-CM Phase 1 Trial
Marianna Fontana, MD, PhD discusses Phase 1 interim results on the CRISPR-based gene-editing therapy, nex-z, for ATTR-CM.
Zerlasiran Achieves Durable Lp(a) Reductions at 60 Weeks, with Stephen J. Nicholls, MD, PhD
Stephen J. Nicholls, MD, PhD discusses the robust efficacy and tolerability of zerlasiran for Lp(a) lowering, paving the way for Phase 3 development.
Ghaith Noaiseh, MD: Nipocalimab Improves Disease Measures, Reduces Autoantibodies in Sjogren’s
Noaiseh discussed data from the DAHLIAS study linking, for the first time, clinical responses, with autoantibody levels.
LEVI-04 Improved Outcomes in Knee Osteoarthritis Compared With Placebo
Over half of patients treated with LEVI-04 had at least a 50% reduction in pain and over 25% had at least a 75% reduction.
Laura Hamant, MD: Standardized Algorithm Increases VTE Prophylaxis Among Children
At NASPGHAN, HCPLive spoke to Hamant about her team’s study that showed their algorithm was linked to increased VTE Prophylaxis among Pediatric IBD.
A. Sidney Barritt, MD: Real-World Data Suggest Benefit of GLP-1 RAs for MASLD
Barritt reviews real-world data about the use and benefits of GLP-1 RAs in patients with MASLD.
B. longum 3562 Improves IBS Severity in Children but Does Not Persist after Intake
Bifidobacterium longum 35624TM reduces IBS symptom severity in children and adolescents, according to a study presented at NASPGHAN 2024.
DZP Improves Disease Activity and Reduces Corticosteroid Use in SLE
The phase 3 PHOENYCS GO trial met its primary endpoint in achieving BICLA response at week 48 compared with placebo.
Kris Kowdley, MD: Elafibranor Remains Safe, Efficacious for PBC Through 3 Years
Kowdley reviews open-label extension data for biochemical response, ALP normalization, and pruritus improvement from the phase 3 ELATIVE study.
Steps to More Accurately Diagnose Oropharyngeal Dysphagia, with Daniel Duncan, MD
At NASPGHAN 2024, HCPLive spoke with Duncan about how treating infants who appear to have reflux may actually result in greater repeat hospital visits.
Elafibranor Shows Sustained Efficacy for PBC, Improves Pruritus and Fatigue
Findings from the open-label extension of the ELATIVE study suggest sustained safety and efficacy for up to 3 years, with improvements in itch and sleep.
Finding a Role for GLP-1 RAs, Incretin Therapies in Heart Failure, with Muthiah Vaduganathan, MD, MPH
Muthiah Vaduganathan, MD, MPH, discusses the need for cardiology to embrace a role for GLP-1 receptor agonists and incretin therapies, with a focus on obesity-related HFpEF.
Navigating News and Updates in Cardiology at AHA 24, with Viet Le, PA-C, DMSc
Viet Le, PA-C, DMSc, breaks down new data and updates from AHA 24, spotlighting 3 specific trials and the applicability of artificial intelligence in care.
Vagus Nerve Stimulation Yields Responses in Refractory Rheumatoid Arthritis
Over one-third of participants had had inadequate responses or intolerance to at least 3 prior b/tsDMARDs.
Muvalaplin, an Oral Lp(a)-Lowering Agent, Shows Promise in Phase 2 KRAKEN Trial
Muvalaplin, an oral treatment, reduced Lp(a) by up to 85% in a 12-week Phase 2 trial presented at AHA 2024.
Diabetes Linked to Worse Transplant-Free Survival in Primary Biliary Cholangitis
Diabetes was associated with an increased risk of liver transplant or death and with liver-specific events in patients with PBC.
Marianna Fontana, MD, PhD: Declines in Kidney Function Frequent in ATTR-CM
Marianna Fontana, MD, PhD describes the prognostic importance of a decline in eGFR in a retrospective cohort of patients with ATTR-CM.
Wei Zhang, MD, PhD: Naltrexone’s GI, Liver Safety for Alcohol Use Disorder Treatment
Zhang explains the safety of different FDA-approved alcohol use disorder drugs in patients with alcohol-associated liver disease.
Tofacitinib Not Superior to Placebo in Systemic Juvenile Arthritis Double-Blind Trial
However, fewer patients experienced flares in the tofacitinib group than in the placebo group, among other positive findings.
Zerlasiran 60-Week Data Reinforce Lp(a) Reductions Observed in ALPACAR-360
Zerlasiran reduced Lp(a) by over 90% at 60 weeks with consistent efficacy and no serious drug-related adverse events, supporting its phase 3 trial progression.