The HCPLive conference coverage page features articles, videos, and expert-led live coverage from major medical meetings throughout the year.
Diabetes Linked to Worse Transplant-Free Survival in Primary Biliary Cholangitis
Diabetes was associated with an increased risk of liver transplant or death and with liver-specific events in patients with PBC.
Marianna Fontana, MD, PhD: Declines in Kidney Function Frequent in ATTR-CM
Marianna Fontana, MD, PhD describes the prognostic importance of a decline in eGFR in a retrospective cohort of patients with ATTR-CM.
Wei Zhang, MD, PhD: Naltrexone’s GI, Liver Safety for Alcohol Use Disorder Treatment
Zhang explains the safety of different FDA-approved alcohol use disorder drugs in patients with alcohol-associated liver disease.
Tofacitinib Not Superior to Placebo in Systemic Juvenile Arthritis Double-Blind Trial
However, fewer patients experienced flares in the tofacitinib group than in the placebo group, among other positive findings.
Zerlasiran 60-Week Data Reinforce Lp(a) Reductions Observed in ALPACAR-360
Zerlasiran reduced Lp(a) by over 90% at 60 weeks with consistent efficacy and no serious drug-related adverse events, supporting its phase 3 trial progression.
Weekend Admission for Acute Liver Failure Linked to Higher Post-Transplant Mortality
Liver transplant waitlisting after a weekend was associated with higher 1-year post-transplant mortality compared with patients listed on a weekday.
Jeffrey Teckman, MD: Predicting Severe Liver Disease Risk in ZZ, SZ AATD
Teckman explains the value of a new predictive algorithm model for determining future risk of portal hypertension, cirrhosis, and liver transplant in AATD.
Bumetanide Nasal Spray Equivalent to Oral, IV Forms for Heart Failure
A nasal spray form of bumetanide reduced tissue swelling from heart failure as effectively as the oral and intravenous formulations.
Sacubtril/Valsartan Lowers Cardiotoxicity Risk Linked to Chemotherapy
Sacubitril/valsartan reduced the risk of heart damage among high-risk cancer patients treated with anthracycline chemotherapy agents.
GLP-1RAs Reduce Risk of Hepatic Decompensation in Alcohol-Associated Liver Disease
GLP-1RA use was associated with a reduced risk of adverse liver outcomes in patients with alcohol-associated liver disease and type 2 diabetes.
Søren Andreas Just, MD, PhD: Developing AI to Mitigate Rheumatologist Shortages for Disease Assessment
Just discussed data from 2 studies demonstrating efficacy of AI assessment compared to clinician assessment.
Study Highlights Racial, Ethnic Disparities in Liver Transplant Waitlisting, Allocation
Compared with non-Hispanic White patients, racial/ethnic minority patients were more likely to be removed from the waitlist and not receive a transplant.
Christian T. Ruff, MD, MPH: Abelacimab Cuts Bleeding Risk Versus Rivaroxaban
Christian. T. Ruff, MD, MPH describes an analysis of AZALEA-TIMI 71 demonstrating the substantial benefit of abelacimab on bleeding outcomes in patients on antiplatelet therapy.
Mediterranean Diet May Help Reduce Risk of Adverse Liver-Related Outcomes in MASLD
High adherence to the Mediterranean diet was linked to a lower risk of liver-related outcomes as measured by the Liver Risk score.
Understanding NUDGLE-FLU Data from AHA 2024, with Ankeet Bhatt, MD, MBA, ScM
Ankeet Bhatt, MD, MBA, ScM, provides additional insight into NUDGE-FLU data he presented at AHA 2024.
NUDGE-FLU Analysis Finds History of Heart Attack Increases Effectiveness of CV Gain Frame Letter
Electronic messages highlighting cardiovascular benefits of flu shots increased vaccination rates by 1.8% in heart attack survivors.
Emapalumab May Improve Response Rates in MAS Treatment
Findings from the first and only controlled study for macrophage activation syndrome were presented at the ACR Convergence.
Barry A. Borlaug, MD: Impact of Tirzepatide on Cardiorenal End-Organ Damage in HFpEF
Barry A. Borlaug, MD describes the beneficial effect of tirzepatide on circulatory pressure-volume overload and end-organ damage in patients with HFpEF and obesity.
Shreena K. Gandhi, MBBS: Recognizing Fibromyalgia as a Continuous Variable, Trait Diagnosis
Gandhi discussed examining social security disability rates and how SSD criteria may clash with a trait disease like fibromyalgia.
ITCH-E: Pruritus Linked to Worse Health-Related Quality of Life in PBC
Patients with PBC and moderate/severe pruritus face a greater health-related quality of life burden and impaired activity than those with no/mild itch.
Minjee Kim, MD: Understanding Sleep’s Impact on Post-Liver Transplant Outcomes
Kim explains how poor sleep is linked to negative impacts on mental health, physical health, and frailty after liver transplantation.
GLORIOUS: Exenatide Lacks Preventive Effect on Organ Injury in Cardiac Surgery
An IV infusion of exenatide during cardiac surgeries involving bypass did not significantly benefit mortality or organ injury compared with placebo.
Oussama Wazni, MD, MBA: OPTION Trial and the Role of LAAC in Atrial Fibrillation
Oussama Wazni, MD, discusses the results of the OPTION trial examining LAAC in atrial fibrillation as well as its reception as AHA 2024.
Obesity-Related Heart Disease Deaths Rose Roughly 180% Since 1999
Obesity-related ischemic heart disease deaths rose from 1999 to 2020, particularly in middle-aged men and Black adults, per CDC WONDER data.
Reducing Treatment Burden of Pegloticase for Uncontrolled Gout, with Orrin Troum, MD
Troum discussed positive efficacy and safety findings from the phase 4 AGILE study.
Exploring CAR T-cell Therapy for Rheumatic/Autoimmune Diseases With Georg Schett, MD
Schett discussed findings from 2 early studies of CD19 CAR T-cell therapy.
TCE Therapy Demonstrates Quick Responses for Systemic Lupus Erthematosus in Early Data
A-319 has been well-tolerated so far and dose-escalation is ongoing in the phase 1 trial.
Elafibranor Improves Predicted Transplant-Free Survival Based on GLOBE, UK-PBC Scores
Treatment with elafibranor (Iqirvo) improved prognostic GLOBE and UK-PBC scores as early as week 4 in the phase 3 ELATIVE trial.
Interim Phase 1 Update Shows Favorable Effect of Nex-z for ATTR-CM
A single dose of nex-z achieved consistent and rapid reductions in serum TTR levels over 12 months of follow-up in patients with ATTR-CM.
VANISH2: Catheter Ablation Viable First-Line Option for Ventricular Tachycardia
Initial catheter ablation achieved a lower risk of a composite primary endpoint event than anti-arrhythmic drug therapy in patients who survived a heart attack.