The HCPLive conference coverage page features articles, videos, and expert-led live coverage from major medical meetings throughout the year.
Better Minority Enrollment Needed in UK Multiple Myeloma Trials
The enrollment distribution was consistent by ethnicity over the course of 18 years, with no change in diversity over time despite there being an increase in the UK in the minority population.
Fuad El Rassi, MD, Tracks COVID-19 and Sickle Cell Disease For a Year
Of the SCD patients who contracted COVID-19, 49% of them visited the Grady Comprehensive Sickle Cell center because of a vaso-occlusive event.
Identifying Distinct Cognitive Profiles Of Adults With SCD May Reduce Morbidity
Data show patients with sickle cell disease identified by distinct cognitive profile should have neurorehabilitation tailored to each unique profile.
Voxelotor May Improve Exercise Capacity In Patients With Sickle Cell Anemia
After 2 months of voxelotor treatment, all patients with sickle cell anemia perceived global improvement, but peak VO2 did not change in 8 of 9 patients.
Voxelotor Shows Significant Reduction in Transfusions, VOCs in Patients with SCD
Data show most patients (60.3%) with sickle cell disease achieved a Hb increase of >1 g/dL during the follow-up period.
Sickle Cell Patients at Increased Risk of COVID-19 Hospitalization
Patients with SCD were not at an increased risk of death or disease complications.
Low Vitamin D Levels Lead to Pain Problems for Sickle Cell Patients
High dose vitamin D supplementation has been linked to fewer pain days and higher physical activity scores for patients with chronic pain.
ARU-1801 Yields Promise for Severe Sickle Cell Disease in Phase 1/2 Trial
New ASH 2021 data for the stem cell transplant therapy suggest it has a durable and safe benefit for adults with severe disease.
Black Patients with Multiple Myeloma Less Likely to Receive Evaluation
Investigators added improvements were needed regarding access to complete diagnostic evaluation among Black patients, citing disparities in care.
Julien Valton, PhD: Repairing the HBB Gene with TALGlobin01
New research on the preclinical product TALGlobin01 reveals the potential impact that gene therapy can have on the future of sickle cell disease treatment.
Atrial Fibrillation More Common in Adults with Sickle Cell Disease
New cohort analysis suggest a heightened risk of atrial fibrillation may be worsening patients' life expectancies.
Novel Lentiviral Vectors Achieve Efficient Correction of Sickling Phenotype
Investigators aimed to improve lentiviral vectors to boost therapeutic β-like globin levels without increasing the mutagenic vector load in hematopoietic stem/progenitor cells.
Gene Therapy RP-L201 Shows Promise in Pediatric LAD-I Cases in Phase 1/2 Results
New data for the Rocket Pharmaceutical gene therapy candidate show durable benefit in patients 6 months out from transplant.
UCB Announces Results on Rozanolixizumab in Generalized Myasthenia Gravis
The global biopharmaceutical company released research data on rozanolixizumab and zilucoplan at the 2021 ASH annual meeting and exposition.
Global SWAY Survey Shows Sickle Cell Patient, Clinician Patterns
An international assessment shows many patients are wary of emergency rooms, and clinicians want more diverse therapies.
Atypical Stroke Linked To Half Of Acute Ischemic Neurological Events in SCD Children
Data show 12 of 25 strokes (48%) in a cohort of children did not met the definition of typical stroke related to sickle cell cerebral vasculopathy.
Giroctocogene Fitelparvovec Well-Tolerated in Hemophilia A Patients
Data from phase 1 and phase 2 of the Alta study was presented at ASH this weekend.
The Need for Contraception Guidance in Sickle Cell Disease
Defined roles and research-informed recommendations are lacking for clinicians navigating birth control with females with sickle cell.
Clonal Tracking Used to Map Genomic Landscape of Sickle Cell Patients
Investigators suggested this approach will allow for comprehensive mapping of the genomic landscape and clonal evolution of stem cells in sickle cell patients
HSCT Does Not Cause Kidney Damage in Sickle Cell Patients
Patients with sickle cell disease often suffer from acute kidney injuries and chronic kidney disease.
Adding Venetoclax to Treatment Regimen of Patients with Multiple Myeloma
Shaji Kumar, MD, presents final Phase 3 data of the BELLINI trial at the ASH 2021 conference.
Survey: Sickle Cell Disease Caregivers Distressed During COVID-19 Pandemic
An ongoing assessment of caregivers considering hydroxyurea initiation for children with sickle cell disease provides a look into how such families are handling telemedicine and the pandemic.
High Velocity Hemodynamics Linked to Cerebral Microvascular VCAM-1 Expression in SCD
Data show the average maximum cortical capillary RBC velocity is significantly greater in sickle cell mice compared to controls.
Why Sickle Cell Disease Clinicians Provide Different Contraceptive Guidance
New ASH 2021 data shows how guidance is still lacking for clinicians responsible for addressing contraception with women with sickle cell disease.
Fish Oil, DASH Diet Partially Alters Lipid Metabolism in Patients with Type 2 Diabetes
Fish oil intervention and DASH diet show no statistically significant effect on glycemic control and adiposity.
Bisphenol-A Linked to Insulin Resistance in Diabetic Patients
Participants with diabetes mellitus specifically were more prone to develop insulin resistance due to BPA exposure as compared to non-diabetic participants
Sortilin 1 Gene Shows Positive Association with Coronary Artery Disease
Data show the relative expression of SORT1 gene was upregulated by 4.438 fold in patients with CAD, compared to control.
New Study Details PWT2D Experiences with Basal Insulin Titration
Of the 416 basal insulin initiators, only one-third of them reached the appropriate fasting blood glucose level.
Phil Zeitler, MD: Risk Factor Development in Youth-Onset Type 2 Diabetes
Dr. Zeitler highlights the long-term microvascular risk complications observed in T2D patients in the TODAY2 observational study.
Greater Reductions in HbA1c in Insulin-Naïve PW2D Treated with Gla-300
These reductions, investigators noted, were slightly greatest yet not statistically significant.