Frank J. Domino, MD

This cohort study looked at the influence of maintaining a Mediterranean diet on telomere length, which is commonly used as a surrogate marker for longevity.

The highly publicized IMPROVE-IT trial was presented at the American Heart Association Scientific Sessions in mid-November. The conclusion of the study being that for those who are at the highest risk, like those who have suffered myocardial infarction, the combination of ezetimibe plus simvastatin lowered the risk of cardiovascular death, myocardial infarction, or stroke. The significance of this risk lowering is relatively minimal and despite years of research showing no benefit, this presentation was the first time when this drug combination resulted in a benefit.

In the era of reperfusion, beta blockers post myocardial infarction appear to have no mortality benefit.

Eating a low carbohydrate diet compared to a low fat diet leads to greater loss of weight as well as a significant reduction in Framingham Risk Score.

The use of fecal immunochemical testing was found to be an effective method for colorectal cancer screening; this study found it led to an 8.4% positivity rate. On subsequent colonoscopy, 40% of those with positive FIT tests had advanced adenomas or colorectal cancer.

This limited systematic review found some evidence of benefit of e-cigarettes for smoking cessation and little evidence of significant adverse outcomes.

This systematic review and meta-analysis hope to determine the influence of non-steroidal anti-inflammatory agent use on depressive symptoms and in those with depression.

Study Shows Feeding Tubes in Advanced Dementia Leads to Worse Outcomes

Two systematic reviews found the efficacy of the two common anti-virals used for influenza to be of questionable benefit.

A look at whether providing free contraception impacts the pregnancy and abortion rates among teenagers.

Just how effective is vitamin D in helping with various conditions? A look at some of the most recent data

A study of the affect prescribing drugs during infancy can have on childhood obesity

A closer look at the usage of niacin for patients with vascular disease

Can a family dinner help fight cyberbullying? A recent study asked just that question.

This review article of recently reported systematic reviews demonstrates the cancer risks and benefits of taking aspirin over 5 years, finding a benefit beginning after 3 years of use.

Determining if a child or adolescent has hypertension is complex and requires use of gender, age, and height specific readings. This study used a simplified approach of systolic and diastolic blood pressure readings compared to height as a screening tool for the diagnosis of hypertension in Chinese children.

Many guidelines recommend the use of acetaminophen (called paracetamol in Europe) and/or NSAIDs for the treatment of acute low back pain. The reason for this is acetaminophen and NSAIDs are relatively safe and effective with regard to managing musculoskeletal pain. This study determined the efficacy of acetaminophen alone vs. placebo for acute low back pain.

This study was designed to determine the dose-response relation between fruit and vegetable consumption and risk of all cause, cardiovascular, and cancer mortality.

Taking a closer look at the relationship between running and cardiovascular mortality

This is a cohort study of over 300,000 children from 2004 through 2008 to determine the relationship between childhood vaccinations and the occurrence of seizures in the first two years of life. This population study came from across the US and was evaluated by the Centers for Disease Control and Prevention in collaboration with a variety of managed care organizations.

Based upon data from the past 17 years of conferences of the International Anti-Viral Society (formerly AIDS Society), the USA HIV Preventions Recommendations Panel issued new preventive care guidelines.

Marijuana use in adolescence results in significant cognitive and behavioral impairments.

Crops raised in a method that meets the organic standard contain more antioxidants than traditionally grown crops. Nevertheless, it remains unproven whether diets with higher antioxidant concentrations provide improved health outcomes.

Despite the general consensus that excessive alcohol consumption should be avoided prior to and during pregnancy, there is very little data on the effects alcohol consumption in early gestation has on birth outcomes.

It is generally assumed a viral infection will get better in "7 days with antibiotics and in roughly a week without them." As it turns out, these estimates are low, especially in children.

For those who fail to quit smoking with varenicline treatment alone, adding a nicotine patch will likely increase the odds of tobacco abstinence at 6 months.

In response to the growing prevalence of gestational diabetes mellitus and its associated morbidities, much attention has been paid to the use of appropriate screening methodologies for the metabolic disorder.

Though it once led to major adverse cardiovascular events, Kawasaki disease has evolved into a condition that is routinely overcome without significant morbidity.

While a variety of surgical procedures can treat menorrhagia in premenopausal women, a recent study added a non-surgical alternative to the mix.

Perhaps, a very simple change in beverage choice could reduce the stroke burden in the United States.