Internal Medicine

In clinical testing, the MD-Logic Artificial Pancreas system significantly improved overnight glucose control and decreased the duration of hypoglycemia in type 1 diabetes patients.

While substantial evidence already shows several genetic and environmental elements factor into immune-mediated rheumatic disease susceptibility, a recent review of hospital admissions data suggests vitamin D deficiency can single-handedly elevate a patient's risk of developing certain chronic conditions within that group of disorders.

Research findings from a group of Midwest-based investigators suggest bipolar disorder (BD) is linked to different illness burdens in binge eaters compared to obese patients who do not experience compulsive episodes of uncontrollable overeating.

Though recent reviews were unable to provide evidence of efficacy for several complementary treatments for rheumatoid arthritis (RA), a group of researchers decided to clinically evaluate the effectiveness of static electric field therapy by high voltage alternating current (EF-HVAC) in the chronic inflammatory autoimmune disorder.

Transforaminal epidural steroid injections (TFEI) have become a more common approach to relieving chronic lumbar radicular pain, but until now, no published clinical reports had directly compared morphine with tramadol for that indication.

Depression patients monitored by physicians and care managers in a collaborative model have better antidepressant medication use and clinical outcomes than those treated in a traditional primary care setting, according to a comparison of the two delivery methods published in the May 2013 issue of Clinical Practice & Epidemiology in Mental Health.

Primary care physicians rate more than 40 percent of hospitalizations resulting from ambulatory care-sensitive conditions (ACSCs) as avoidable with effective preventive care and disease management.

With strong clinical evidence and adverse event reports linking Daiichi Sankyo's high blood pressure medication Benicar (olmesartan medoxomil) to the gastrointestinal condition known as sprue-like enteropathy, the US Food and Drug Administration has approved changes for the drug's label to include a warning about that risk.

Researchers at the Hanyang University College of Medicine set the record straight on the association between IBS symptoms and methane and hydrogen gas produced by intestinal fermentation of lactulose and excreted in the breath during lactulose breath test.

Steven P. Levine, MD, says new research on an old medicine has injected excitement into major depressive disorder treatment.

Study results support early treatment, even in patients with a high CD4 count.

HIV-infected patients face increased risk of myocardial infarction, as well as higher risk for ART-associated dyslipidemia and insulin resistance.

A panel of experts discuss information from late-breaking abstracts presented at IAS 2013, including information on the two patients who remain HIV-free following stem cell transplant.

Two male patients with prolonged HIV infection who received hematopoietic stem cell transplants still remain virus-free several consecutive weeks after their antiretroviral treatments were discontinued this spring.

The US Food and Drug Administration (FDA) has expanded the indications of Novartis Pharmaceuticals Corp.'s transdermal therapy for Alzheimer's disease to include the treatment of patients with severe stages of the neurological disorder.

As pre-exposure prophylaxis (PrEP) remains at the forefront of HIV prevention research, clinical trial investigators provided an update on recent oral and topical PrEP efficacy studies at the second plenary session of the 7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2013), held June 30 to July 3 in Kuala Lumpur, Malaysia.

Consolidated guidelines from the World Health Organization recommend starting treatment when a patient's CD4 count falls below 500, and also recommend a new first-line ART regimen.

The US Food and Drug Administration (FDA) has approved Noven Pharmaceuticals Inc.'s once-daily Brisdelle (paroxetine) capsules to reduce moderate to severe hot flashes and night sweats that can last up to five years in menopausal women.

Study shows gluten alters bowel functions in patients with IBS-D and that removal of gluten from the diet may reduce the frequency of bowel movements.

Recognizing that melatonin secretion from the gastrointestinal (GI) tract improves abdominal pain in irritable bowel syndrome (IBS) but decreases with age, Polish researchers from the Medical University of Lodz aimed to define the effect of administering melatonin in postmenopausal women with different predominating IBS symptoms.

Results of a pair of phase 3 placebo-controlled clinical studies conducted by a worldwide team of researchers have deemed Merck's Isentress (raltegravir) antiretroviral treatment safe, tolerable, and effective in multidrug-resistant HIV patients who are naïve to integrase inhibitors.

By adopting a comprehensive set of case management policies for the care of diabetic and hyperglycemic patients, Johns Hopkins Hospital improved in-hospital mortality rate, reduced length of stay, and reduced hyperglycemia.

Exposure to insulin glargine and metformin did not cause increased risk of cancer or worse cancer outcomes.

Results of a three-year trial of the experimental GLP-1 receptor agonist albiglutide showed that it had a better effect on HbA1c, fasting blood glucose, and body weight than two comparator drugs.

Prescription-strength doses of vitamin D improve highly prevalent comorbidities among diabetic women, such as depression and pain, and also improve risk factors such as excess weight and high blood pressure.

The US Food and Drug Administration has awarded "breakthrough therapy" status to a synthetic copy of a naturally occurring human hormone for the treatment of acute heart failure (AHF), drug developer Novartis announced today.

The chronic constipation associated with conditions such as IBS can lead to serious health complications if left untreated.

Nearly two years after Eli Lilly and Co. halted a pair of clinical trials on its gamma-secretase inhibitor for Alzheimer's disease following the candidate's failure to demonstrate results superior to placebo, the drug maker has terminated a phase 2 study of its investigational beta-secretase (BACE) inhibitor for the same neurological condition - this time citing liver abnormalities.

Hypertriglyceridemia combined with insulin resistance may lead to increased platelet activation in women with polycystic ovary syndrome (PCOS).

Insulin sensitivity improved after three nights of adequate sleep in nondiabetic men after days of inadequate sleep.