Pain

No studies had determined the genetic cause of early-onset gout cases until a group of Japanese researchers discovered a the same genomic dysfunction among the patients.

Transforaminal epidural steroid injections (TFEI) have become a more common approach to relieving chronic lumbar radicular pain, but until now, no published clinical reports had directly compared morphine with tramadol for that indication.

Researchers at the Hanyang University College of Medicine set the record straight on the association between IBS symptoms and methane and hydrogen gas produced by intestinal fermentation of lactulose and excreted in the breath during lactulose breath test.

Recognizing that melatonin secretion from the gastrointestinal (GI) tract improves abdominal pain in irritable bowel syndrome (IBS) but decreases with age, Polish researchers from the Medical University of Lodz aimed to define the effect of administering melatonin in postmenopausal women with different predominating IBS symptoms.

Prescription-strength doses of vitamin D improve highly prevalent comorbidities among diabetic women, such as depression and pain, and also improve risk factors such as excess weight and high blood pressure.

A high-potency probiotic supplement that mimics the effect of morphine in the gut may reduce the development of visceral pain in irritable bowel syndrome (IBS).

Pain is a common symptom in patients with multiple sclerosis (MS), with some studies showing that clinically significant pain associated with their disease is experienced by more than half of patients with MS.

Results of a recent clinical trial by researchers at the Department of Rehabilitation Medicine in the Affiliated Tenth People's Hospital of Tongji University, in Shanghai, China, have deemed locally injected methylcobalamin more effective than its orally administered counterpart as a treatment for subacute herpetic neuralgia.

The agency rejected a request from the painkiller's manufacturer to outlaw generic versions lacking tamper-resistant features just weeks after deciding the opposite way for generic versions of OxyContin.

As irritable bowel syndrome (IBS) remains a complicated condition to treat with an etiology that's still unknown, it's difficult for physicians to find the best proven therapies among new remedies and the variety of pharmacological and nondrug options they have been trying for years.

Treating postherpetic neuralgia patients with the oral opioid agonist tramadol may significantly reduce moderate to severe nerve pain.

Patients taking linaclotide experience clinically meaningful improvement in abdominal and bowel symptoms, which closely correlate with the US Food and Drug Administration's new criteria for irritable bowel syndrome with constipation (IBS-C).

With what we now know about opioid misuse and abuse, we need to take the necessary steps to ensure that only abuse-resistant/deterrent medications are used for our patients taking ER/LA opioid medications.