Opinion

Video

IgAN vs Other Glomerular Diseases

Author(s):

Jonathan Barratt, PhD, FRCP,Anuja Java, MD

Key Takeaways

  • IgA nephropathy involves aberrant glycosylation of IgA1, leading to immune complex deposition in the glomerular mesangium.
  • This condition is distinct from other glomerular diseases due to its specific association with IgA1 and mucosal immune responses.
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Panelists discuss the immune system dysregulation underlying IgA nephropathy and highlight how this mechanism differs from those seen in other glomerular diseases.

Can you explain the immune system dysregulation that leads to IgA nephropathy? How does this differ from other glomerular diseases?

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