Significance of Proteinuria for Potential IgAN

Key Takeaways

• Clinicians evaluate proteinuria significance in IgAN by assessing quantity and persistence, using 24-hour urine collection or spot urine protein-to-creatinine ratio.
• Proteinuria levels exceeding 1g/day typically prompt further investigation, especially if persistent or in the nephrotic range.
• Episodic macroscopic hematuria with upper respiratory infections, microscopic hematuria, and hypertension are diagnostic red flags suggesting IgAN over other kidney disorders.