Differential Diagnoses of IgAN

Author(s):

Jonathan Barratt, PhD, FRCP,Anuja Java, MD

Key Takeaways

IgA nephropathy diagnosis involves clinical evaluation, laboratory tests, and renal biopsy to differentiate from similar glomerular diseases.
Renal biopsy with immunofluorescence microscopy is crucial, revealing mesangial IgA deposits specific to IgAN.
Lupus nephritis shows full-house immunofluorescence staining, while membranous nephropathy has subepithelial immune deposits.
Accurate differentiation is essential for appropriate disease management and treatment strategies.

Panelists discuss how clinicians can differentiate IgA nephropathy from other glomerular diseases, such as lupus nephritis and membranous nephropathy, that may present with similar clinical features.

EP: 1.Overview of IgAN and Its Common Symptoms

EP: 2.IgAN Progression

EP: 3.IgAN vs Other Glomerular Diseases

EP: 4.Biomarkers for IgAN

EP: 5.Genetic Screening for IgAN

EP: 6.Impact of IgAN on Quality of Life

EP: 7.Misdiagnosis and Barriers to Early Detection of IgAN

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EP: 8.Differential Diagnoses of IgAN

EP: 9.Significance of Proteinuria for Potential IgAN

EP: 10.Proteinuria Variability and IgAN Diagnosis

EP: 11.Biomarkers and Improving IgAN Diagnostic Accuracy

EP: 12.Primary Treatment Goals for Patients With IgAN

How do clinicians differentiate IgANIgA nephropathy from other glomerular diseases, such as lupus nephritis or membranous nephropathy, which can present with similar clinical features?