Overview of IgAN and Its Common Symptoms

Author(s):

Jonathan Barratt, PhD, FRCP,Anuja Java, MD

Key Takeaways

IgA nephropathy involves IgA antibody deposition in glomeruli, causing inflammation and potential kidney damage.
Common symptoms include hematuria, proteinuria, and hypertension, though some patients may be asymptomatic.
Asymptomatic cases are frequently diagnosed incidentally during routine examinations, highlighting the disease's insidious nature.
No distinct clinical subtypes are widely recognized, but variability in progression and treatment response suggests underlying heterogeneity.

Panelists discuss how IgA nephropathy presents in patients, often remaining asymptomatic until significant progression occurs, and explore the various subtypes that exhibit distinct clinical features.

Now Viewing

EP: 1.Overview of IgAN and Its Common Symptoms

EP: 2.IgAN Progression

Please provide a brief overview of IgA nephropathy (IgAN) for those unfamiliar with the disease state? .
How does it manifest in patients, and what are the typical symptoms?
In your experience, how often do you see cases where the disease may be asymptomatic until it has progressed significantly?
Are there specific subtypes of IgAN with distinct clinical features?