Endocrinology

Gilead Sciences recently filed a New Drug Application with the US Food and Drug Administration for a single-tablet regimen to treat chronic infection of all forms of the hepatitis C virus.

A new analysis of trial data shows that patients with exocrine pancreatic insufficiency benefit about as much from pancrelipase delayed-release capsules (Creon) whether or not they have diabetes mellitus.

Sleep apnea and depression are both serious conditions patients deal with on a daily basis. A recent study looked at a possible connection between the two and how doctors can better treat these patients.

The following slides discuss the benefits of weight loss on insulin sensitivity, costs of bariatric surgery vs conventional care, and more.

The much buzzed about Evaluation of Lixisenatide in Acute Coronary Syndrome (ELIXA) trial has been tracking the medication in patients with type 2 diabetes. An update on the outcomes was provided at the 10th Annual Cardiometabolic Health Congress (CMHC 2015) in Boston, Massachusetts.

A combination of two drugs can combat one type of pancreatic cancer, according to a study published in the Journal of the National Cancer Institute.

The US Preventive Services Task Force's updated recommendations on screening for diabetes type 2 have the American Medical Association's (AMA) president fuming.

Study results suggest that screening for metabolic syndrome among patients taking antipsychotic medications occurs far less frequently than recommended by the guidelines.

The evidence indicates resistant starches improve glucose metabolism beyond what would be expected from its reduced glycemic index.

Studies have shown that excessive caloric intake accelerates aging, whereas caloric restriction has been shown to lengthen lifespan and reduce the risk of several diseases.

When it comes to toxicology, the dose often makes the poison. Consider this report of a case of apparent mineralocorticoid excess apparently caused by licorice root extract.

As part of a multi-institutional effort, researchers in the fields of proteomics, lipidomics, and metabolomics will collaborate to discover more effective ways of predicting which patients with type 1 diabetes are at greater risk for developing kidney disease.

Researchers in Australia recently reported that the immune signaling protein NLRP1 plays a key role in metabolism by activating fat-burning processes when the body's energy intake is too high.

A clinical trial with a choline-rich structured lipid found that daily intake can significantly reduce choline depletion in cystic fibrosis patients with exocrine pancreatic insufficiency.

There are approximately 500,000 new cases of heart disease every year, and with heart failure being a potential complication in many of those cases, effective therapies are necessary.

Hyperkalemia can be fatal and there is a serious need to provide improved treatment options.

Study results show asthma severity can be controlled with weight loss in obese patients.

Non-diabetic obese patients experienced many benefits from taking a GLP-1 agonist.

At the 2015 Cardiometabolic Health Congress, Christie M. Ballantyne, MD, moderated a panel discussion focusing on current cholesterol guidelines and several changes that may be coming soon.

Lipid resuscitation therapy was identified in 1998 as an effective treatment for local anesthetic systemic toxicity. Since then, researchers have developed a better understanding of the risk factors involved and the manner in which lipids work, using both dynamic scavenging and direct cardiotonic effects.

Elevated levels of triglycerides have been proven time and time again to be linked to cardiovascular disease. While it can be a challenging condition to control, it opens the door for treatments.

It wasn't long ago that researchers first identified a piece of DNA that regulates cholesterol. This gene has been recently developed into a cholesterol-lowering agent and it's time to address where we go from here.

Type 1 diabetes mellitus (T1DM) is treated by necessity with insulin analogues in an attempt to mimic normal physiological insulin profiles. Regardless, this approach is rarely completely successful and most T1DM patients experience fluctuating or suboptimal glucose control, significant hypoglycemia and microvascular tissue complications.

Most adults in developed nations struggle with their weight. Ample quantities of high-quality foods (and plenty of sugar- and fat-laden snacks) do more than just nourish us. They allow us to overindulge; in fact, they tend to make people eat mindlessly.

What effect did GLP-1 agonists have on brain glucose metabolism?

It's a constant question of whether physician decision making has benefitted the patients or not.

Cystic dilatation of the bile duct (usually called choledochal cyst)-is a rare condition that causes numerous complications, such as chronic pancreatitis, which is the most common cause of exocrine pancreatice insufficiency in adults.

Our Oct. list of endocrinology news & research includes conflicting opinions on the obesity paradox and self-harm issues after bariatric surgery.

Positive hepatitis C infection may increase risk for liver damage as well as future heart problems, according to findings published in The Journal of Infectious Diseases.

Though it is still in development, a blood test may be able to detect pancreatic cancer in early stages, according to a proof of concept study published in Cancer Prevention Research.