Rheumatology

Recent findings suggest that methotrexate reduces humoral vaccination response against COVID-19 in older, but not younger, patients with rheumatoid arthritis.

Risankizumab showed linear and time-independent pharmacokinetics in patients with active psoriatic arthritis and was comparable to those with plaque psoriasis.

Dr. Veronica Anwuri discusses how apremilast (Otezla), the first oral, non biologic treatment option for plaque psoriasis can address the systemic pain associated with psoriatic arthritis.

Take 5 minutes to catch up on Rheumatology Network's highlights from the week ending October 15, 2022.

“Failed or inadequate response to disease-modifying antirheumatic drugs (DMARDs) is associated with poor prognosis," investigators noted.

Supplementation with probiotics was shown to improve hyperuricemia and symptoms of gout, among other inflammatory diseases.

Higher PGI scores, which signify better quality of life, were positively correlated with all SF-12 subscales except for role emotional.

The neutralizing serum activity against variants in patients receiving methotrexate only increased 20-23-fold after booster vaccination, while the serum activity in those in the non-immunosuppressed group increased 67-73-fold.

The study examined ozoralizumab without concomitant therapy, as methotrexate cannot be given to all patients with rheumatoid arthritis due to inadequate efficacy and tolerability.

How much do you know about the Rheumatic Disease Report Card and how it relates to your practice? Test your knowledge with this quiz.

Preventing chronic damage accrual is one of the top treatment targets, as it is linked to increased mortality and decreased quality of life.

Take 5 minutes to catch up on Rheumatology Network's highlights from the week ending October 8, 2022.

A statistically significant elevated risk of SLE was shown among women with low sleep, depression, and bodily pain when compared with those without these concomitant issues.

After undergoing arthroscopic knee or shoulder surgery, patients treated with an opioid-sparing postoperative pain management protocol had reduced opioid use compared with standard treatment.

The single-center, cross-sectional study assessed chair rise time, gait speed, and grip strength to determine the prevalence of sarcopenia.

Drs. Anne E. Winkler and Kristi V. Mizelle share practice pearls to optimize the management of patients of patients diagnosed with lupus.

Experts in rheumatology provide an overview of novel treatment options currently under investigation for the treatment of systemic lupus erythematosus and lupus nephritis.

Kristi V. Mizelle, MD, MPH, FACR comments on long term efficacy data on the use of biologics in lupus, with a focus on preventing organ damage.

“Importantly, several different immunomodulation agents may be effective for increasing treatment response rates and seem well tolerated by patients with uncontrolled gout."

This MBDA score has been validated to correlate with the disease activity score, including a 28-joint count and CRP (DAS28-CRP), in patients with rheumatoid arthritis.

"Surveys of patients with SLE and other autoimmune and inflammatory rheumatic diseases have identified vaccine hesitancy in up to 50% of patients, which may be related to concerns about side effects, potential disease flares, or lack of data among patients with SLE.”

Findings demonstrate the utility of machine learning in aiding clinical risk stratification within a complex patient cohort.

Results underline the importance of psychiatric evaluation and treatment in patients with fibromyalgia.

The findings of this study of anti-CD19 directed CAR T cell therapy offers new hope for the most severe and refractory cases.

Take 5 minutes to catch up on Rheumatology Network's highlights from the week ending October 1, 2022.

A long-term, post-authorization safety study of adverse events was performed for patients with PsO and/or PsA exposed to apremilast.

The 3-stage Delphi exercise used the expertise of medical and health care professionals with experience in treating patients with fibromyalgia. Treatment recommendations included exercise, education, cognitive behavioral therapy, mindfulness, and mind-body exercises.

Anne E. Winkler, MD, PhD, MACP shares her approach to treatment in patients with lupus post treatment with immunosuppressants with a focus on treatment sequencing.

Drs Anne E. Winkler and Kristi V. Mizelle explore relevant treatment options for a patient with lupus nephritis and highlight efficacy and safety considerations.

Although the proportion of women treated with biologics continues to grow, data on treatment recommendations among both physicians and female patients of childbearing age remain limited.