Differential Diagnosis of PBC

Key Takeaways

• PBC is more prevalent in middle-aged women and presents with fatigue and pruritus, aiding in clinical differentiation.
• The presence of antimitochondrial antibodies (AMAs) is a key serological marker, found in 95% of PBC patients.
• Elevated alkaline phosphatase levels are indicative of PBC, assisting in distinguishing it from other liver diseases.
• Histological features include non-suppurative destructive cholangitis and bile duct destruction, differentiating PBC from other cholestatic liver diseases.