Opinion

Video

Pathophysiology of PBC

Key Takeaways

  • PBC involves autoimmune-mediated destruction of intrahepatic bile ducts by autoreactive T lymphocytes, leading to cholestasis.
  • Accumulation of toxic bile acids due to cholestasis causes hepatocellular damage and inflammation.
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The panelists explain the pathophysiology of primary biliary cholangitis (PBC), highlighting how immune-mediated processes contribute to progressive liver damage in affected patients.

Video content above is prompted by the following:

  • Could you explain the underlying pathophysiology of PBC and how it contributes to liver damage?
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