Disease Progression and Extrahepatic Manifestations of PBC

Author(s):

Nancy Reau, MD,John Vierling, MD, FACP, FAASLD, AGAF

Key Takeaways

Vitamin deficiencies, especially fat-soluble ones, are prevalent in PBC due to malabsorption issues.
Osteoporosis is a major concern in PBC, often linked to chronic cholestasis and vitamin D deficiency.
MASH can co-occur with PBC, further complicating liver health and management.
Autoimmune conditions, like Sjögren's syndrome and thyroid disorders, frequently accompany PBC.
Obesity exacerbates liver disease progression in PBC, complicating management strategies.

The panel of experts examine major complications and comorbidities associated with primary biliary cholangitis (PBC), including vitamin deficiencies, osteoporosis, and conditions like metabolic-associated steatohepatitis (MASH), autoimmune disorders, and obesity.

EP: 1.Pathophysiology of PBC

EP: 2.Presentation and Diagnosis of PBC

EP: 3.Differential Diagnosis of PBC

Now Viewing

EP: 4.Disease Progression and Extrahepatic Manifestations of PBC

Video content above is prompted by the following:

What are some major complications and comorbidities associated with PBC (eg, vitamin deficiency, osteoporosis, comorbid conditions such as MASH, autoimmune conditions, obesity)?