Disease Progression and Extrahepatic Manifestations of PBC

Author(s):

Nancy Reau, MD,John Vierling, MD, FACP, FAASLD, AGAF

Key Takeaways

Vitamin deficiencies, especially fat-soluble ones, are prevalent in PBC due to malabsorption issues.
Osteoporosis is a major concern in PBC, often linked to chronic cholestasis and vitamin D deficiency.
MASH can co-occur with PBC, further complicating liver health and management.
Autoimmune conditions, like Sjögren's syndrome and thyroid disorders, frequently accompany PBC.
Obesity exacerbates liver disease progression in PBC, complicating management strategies.

The panel of experts examine major complications and comorbidities associated with primary biliary cholangitis (PBC), including vitamin deficiencies, osteoporosis, and conditions like metabolic-associated steatohepatitis (MASH), autoimmune disorders, and obesity.

EP: 1.Pathophysiology of PBC

EP: 2.Presentation and Diagnosis of PBC

EP: 3.Differential Diagnosis of PBC

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EP: 4.Disease Progression and Extrahepatic Manifestations of PBC

EP: 5.Second-Line Treatments and Management of Symptoms in PBC

EP: 6.Treatment Goals and First-Line Therapy in PBC

EP: 7.Seladelpar for Treatment of PBC

EP: 8.PPAR Agonists for Treatment of PBC

EP: 9.Elafibranor and Choosing Amongst PPAR Agonists in PBC

EP: 10.Pruritus Control With PPAR Agonists in PBC

EP: 11.Integration of PPAR Agonists in Treatment Landscape of PBC

EP: 12.Treatment Response to PPAR Agonists and Other Therapies in PBC

EP: 13.Thoughts on the Current State of PBC Management

EP: 14.Outcomes and Adoption of PPAR Agonists in PBC

Video content above is prompted by the following:

What are some major complications and comorbidities associated with PBC (eg, vitamin deficiency, osteoporosis, comorbid conditions such as MASH, autoimmune conditions, obesity)?