Opinion

Video

Elafibranor and Choosing Amongst PPAR Agonists in PBC

Key Takeaways

  • Elafibranor, a PPAR-δ agonist, has demonstrated long-term efficacy and safety in treating primary biliary cholangitis (PBC).
  • Elafibranor and seladelpar both improve liver function in PBC, but differ in receptor selectivity and side effect profiles.
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The panel of experts examine the long-term data for the recently FDA-approved PPAR-δ agonist elafibranor in the treatment of primary biliary cholangitis (PBC), comparing its clinical findings with those of seladelpar, and explores how to choose the right peroxisome proliferator-activated receptor (PPAR) agonist and assess treatment effectiveness.

Video content above is prompted by the following:

  • The FDA recently approved another PPAR-δ agonist, elafibranor, for PBC. Could you discuss the long-term data of this agent? 
    • How do clinical findings for elafibranor compare with those of seladelpar?
    • How do you choose the right PPAR agonist for treating PBC, and how do you know if the treatment is working?
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