Treatment Response to PPAR Agonists and Other Therapies in PBC

Key Takeaways

• PBC involves autoimmune-mediated destruction of intrahepatic bile ducts by autoreactive T lymphocytes, leading to cholestasis.
• Accumulation of toxic bile acids due to cholestasis causes hepatocellular damage and inflammation.
• Chronic inflammation from bile duct destruction results in fibrosis and cirrhosis over time.
• Genetic predispositions and environmental factors play significant roles in the etiology and progression of PBC.