Gastroesophageal Reflux Disease (GERD)

The NDA submission was supported by positive data from the phase 3 PHALCON-NERD-301 study and has been assigned a standard 10-month review with a PDUFA target action date of July 19, 2024.

While more studies are needed to ensure the safety of long-term therapy with PCABs, this study establishes a role for the use of vonoprazan in the healing and maintenance of healing in patients with erosive esophagitis.

VOQUENZA® provides quicker healing than Lansoprazole, according to an FDA-approved Phase 3 study

From a novel acne cream to a breakthrough depression drug, a half-dozen agent decisions are coming through in the coming 6 months.

The results also show 10.3% of the patients with celiac disease that was histopathological confirmed were seronegative to Anti-TtG-IgA, but seropositive to anti-DGP-IgA and/or Anti-DGP-IgG.

From new ACG GERD guidelines to the efficacy of colonoscopies, our latest issue addresses topics changing practice and stirring conversation.

A review of changes to clinical, dietary and screening strategies for patients with GERD.

Nearly half of patients treated with vonoprazan 10 mg and 20 mg achieved more 24-hour heartburn free days compared to participants treated by placebo.

The median DeMeester score decreased from 32-3.7 following LTF.

The new recommendations call for posterior partial fundoplication over total posterior or anterior 90° fundoplication in adult patients with GERD and anterior >90° fundoplication as an alternative.

Both post-transplant PPI and histamine-2 receptor antagonist use were independently associated with reduced risk of 1-year mortality.

DASH diet was inversely associated with NAFLD risk, independent of BMI changes.

The long-term efficacy of fundoplication surgery has not previously been explored for the management of the symptoms of GERD.

In data presented at AAD, investigators found increased odds of GERD in patients with rosacea compared to a control group without rosacea.

The guidelines focus on diagnosing and screening for Barrett’s esophagus and esophageal adenocarcinoma.

There is a significant direct correlation between post-reflux swallow-induced peristaltic wave index and mean nocturnal baseline impendence for patients with GERD.

The endomina system can be affixed to various testing standard endoscopies for a bendable therapeutic channel.

Diagnosing patients with classic GERD symptoms such as heartburn and regurgitation call for an 8-week trial of empiric proton pump inhibitors once daily prior to a meal.

Taste scores were significantly correlated with depression scores for both patients with irritable bowel syndrome and functional constipation.

Despite conflicting data, investigators form Spain found that gastroesophageal reflux disease and asthma are bidirectional, with each disease exacerbating each other.

Vonoprazan has shown more potent acid inhibitory effects than PPI.

New data has investigators caution against the discontinuation of ulcerative colitis treatment, due to threat of relapse.

A cohort assessment shows a 57% increased risk of pediatric asthma development among children given PPIs to treat gastrointestinal tract disorders.

Investigators look at persistent symptoms for GERD patients taking proton pump inhibitors.

In a comparison, investigators find that surgery is more successful in treating GERD patients who do not respond to protein pump inhibitors.