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Spotlight -

This Year In Medicine 2025

Opinion|Videos|December 12, 2025

Understanding the FDA-Approved TYK2 Inhibitor in Psoriasis

Author(s)Christopher G. Bunick, MD, PhD, April W. Armstrong, MD, MPH

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Episodes in this series

EP. 1 Cytokine Pathways and Their Impact on Plaque Psoriasis

EP. 1 Cytokine Pathways and Their Impact on Plaque Psoriasis

EP. 2 Current Standard of Care and Treatment Options in Psoriasis

EP. 2 Current Standard of Care and Treatment Options in Psoriasis

EP. 3 Role of Mechanisms of Action in Treatment Decisions and Personalized Care in Psorias

EP. 3 Role of Mechanisms of Action in Treatment Decisions and Personalized Care in Psorias

EP. 4 Challenges with Current Psoriasis Therapies

EP. 4 Challenges with Current Psoriasis Therapies

EP. 5 Therapeutic Potential of TYK2 Inhibition in Psoriasis

EP. 5 Therapeutic Potential of TYK2 Inhibition in Psoriasis

EP. 6 Selectivity of TYK2 Inhibition in Psoriasis

EP. 6 Selectivity of TYK2 Inhibition in Psoriasis

EP. 7 Understanding the FDA-Approved TYK2 Inhibitor in Psoriasis

EP. 7 Understanding the FDA-Approved TYK2 Inhibitor in Psoriasis

EP. 8 Efficacy and Safety of Zasocitinib in Psoriasis and the Ideal Candidates for TYK2 Inhibitors

EP. 8 Efficacy and Safety of Zasocitinib in Psoriasis and the Ideal Candidates for TYK2 Inhibitors

EP. 9 Opportunities for TYK2 Inhibition in Moderate Psoriasis

EP. 9 Opportunities for TYK2 Inhibition in Moderate Psoriasis

EP. 10 Other Emerging TYK2 Inhibitors in Psoriasis

EP. 10 Other Emerging TYK2 Inhibitors in Psoriasis

EP. 11 Therapeutic Potential of TYK2 Inhibition in Psoriatic Arthritis

EP. 11 Therapeutic Potential of TYK2 Inhibition in Psoriatic Arthritis

EP. 12 Shared Decision-Making Strategies with TYK2 Inhibition and Future Direction in Psoriasis Care

EP. 12 Shared Decision-Making Strategies with TYK2 Inhibition and Future Direction in Psoriasis Care

Deucravacitinib, approved in 2022, was the first selective TYK2 inhibitor for moderate-to-severe psoriasis. Can you describe its mechanism of action?

What are your impressions of the recently published long-term data for deucravacitinib in plaque psoriasis, which demonstrated sustained efficacy and a consistent safety profile through five years of treatment?

How does this data influence your perception of its role in long-term disease management?

Which patients are ideal candidates for deucravacitinib?

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